Research

My research lab aims to develop a smart hydrogel system characterized by dynamic crosslinks and tunable properties to better mimic the dysregulation of tumor ECM. This biomimetic microenvironment will facilitate the investigation of the remodeling and dynamism between cells and the matrix, ultimately providing insights into the mechanisms underlying tumor progression and the efficacy of therapeutic interventions.

My research lab aims to tackle these issues by developing on-demand, customized in vitro models to streamline the fabrication of tumor spheroids and patient-derived tumor organoids. These models will be employed for drug screening and precision medicine, enabling the exploration of various cancer treatments. This approach will facilitate the investigation of how factors such as sex, age, and lifestyle impact treatment responses. 

We aim to develop an in situ forming hydrogel system with stimuli-responsive properties that can significantly enhance intratumoral immunotherapy. This approach allows for precise spatiotemporal control over local administration, facilitating increased accumulation of immune therapeutics at targeted sites.